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Meso Scale Diagnostics LLC serum nfl concentration
Serum Nfl Concentration, supplied by Meso Scale Diagnostics LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+nfl+concentration/serum+nfl+concentration/pm35585374-80-361-365
Average 90 stars, based on 1 article reviews
serum nfl concentration - by Bioz Stars, 2026-09
90/100 stars

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Variant Assay:

Article Title: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Article Snippet: .. SOD1 Variant Selection ATLAS is enrolling carriers of gene variants associated with high or complete penetrance and rapidly progressive Fig. 2 Illustration of decision rules for the primary endpoint Number of participants with emegence of clinically manifest ALS in the tofersen-treated group Number of participants with emegence of clinically manifest ALS in placebo group 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Green region repre nting rejecting H0 ALS amyotrophic lateral sclerosis, H0 null hypothesis 1 3 0 100 200 300 400 500 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.43 0 200 400 600 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.58 0 250 500 750 1000 1250 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.75 0 100 200 300 400 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.5 0 100 200 300 400 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 0 5000 10,000 15,000 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 Plasma NfL concentration (Siemens 2020) Plasma NfL concentration (Quanterix 2020) Months to/since onset Serum NfL concentration (Meso Scale 2018 [27]) Months to/since onset Serum NfL concentration (Quanterix 2020) Months to/since onset Serum pNfH concentration (Euroimmun 2019 [26]) Months to/since onset Serum pNfH concentration (ProteinSimple 2020) Months to/since onset Months to/since onset 30–39 40–49 50–59 60–69 70–79 Age group, years NF neurofilament, NfL neurofilament light chain, pNfH phosphorylated neurofilament heavy chain 1 3 disease. ..

Selection:

Article Title: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Article Snippet: .. SOD1 Variant Selection ATLAS is enrolling carriers of gene variants associated with high or complete penetrance and rapidly progressive Fig. 2 Illustration of decision rules for the primary endpoint Number of participants with emegence of clinically manifest ALS in the tofersen-treated group Number of participants with emegence of clinically manifest ALS in placebo group 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Green region repre nting rejecting H0 ALS amyotrophic lateral sclerosis, H0 null hypothesis 1 3 0 100 200 300 400 500 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.43 0 200 400 600 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.58 0 250 500 750 1000 1250 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.75 0 100 200 300 400 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.5 0 100 200 300 400 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 0 5000 10,000 15,000 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 Plasma NfL concentration (Siemens 2020) Plasma NfL concentration (Quanterix 2020) Months to/since onset Serum NfL concentration (Meso Scale 2018 [27]) Months to/since onset Serum NfL concentration (Quanterix 2020) Months to/since onset Serum pNfH concentration (Euroimmun 2019 [26]) Months to/since onset Serum pNfH concentration (ProteinSimple 2020) Months to/since onset Months to/since onset 30–39 40–49 50–59 60–69 70–79 Age group, years NF neurofilament, NfL neurofilament light chain, pNfH phosphorylated neurofilament heavy chain 1 3 disease. ..

Clinical Proteomics:

Article Title: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Article Snippet: .. SOD1 Variant Selection ATLAS is enrolling carriers of gene variants associated with high or complete penetrance and rapidly progressive Fig. 2 Illustration of decision rules for the primary endpoint Number of participants with emegence of clinically manifest ALS in the tofersen-treated group Number of participants with emegence of clinically manifest ALS in placebo group 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Green region repre nting rejecting H0 ALS amyotrophic lateral sclerosis, H0 null hypothesis 1 3 0 100 200 300 400 500 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.43 0 200 400 600 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.58 0 250 500 750 1000 1250 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.75 0 100 200 300 400 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.5 0 100 200 300 400 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 0 5000 10,000 15,000 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 Plasma NfL concentration (Siemens 2020) Plasma NfL concentration (Quanterix 2020) Months to/since onset Serum NfL concentration (Meso Scale 2018 [27]) Months to/since onset Serum NfL concentration (Quanterix 2020) Months to/since onset Serum pNfH concentration (Euroimmun 2019 [26]) Months to/since onset Serum pNfH concentration (ProteinSimple 2020) Months to/since onset Months to/since onset 30–39 40–49 50–59 60–69 70–79 Age group, years NF neurofilament, NfL neurofilament light chain, pNfH phosphorylated neurofilament heavy chain 1 3 disease. ..

Concentration Assay:

Article Title: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Article Snippet: .. SOD1 Variant Selection ATLAS is enrolling carriers of gene variants associated with high or complete penetrance and rapidly progressive Fig. 2 Illustration of decision rules for the primary endpoint Number of participants with emegence of clinically manifest ALS in the tofersen-treated group Number of participants with emegence of clinically manifest ALS in placebo group 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Green region repre nting rejecting H0 ALS amyotrophic lateral sclerosis, H0 null hypothesis 1 3 0 100 200 300 400 500 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.43 0 200 400 600 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.58 0 250 500 750 1000 1250 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 12, average number of visits = 2.75 0 100 200 300 400 Pl as m a N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.5 0 100 200 300 400 –90 –80 –70 –60 –50 –40 –30 –20 –10 0 10 Se ru m N fL c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 0 5000 10,000 15,000 Se ru m p N fH c on ce nt ra tio n (p g/ m L) N = 14, average number of visits = 3.14 Plasma NfL concentration (Siemens 2020) Plasma NfL concentration (Quanterix 2020) Months to/since onset Serum NfL concentration (Meso Scale 2018 [27]) Months to/since onset Serum NfL concentration (Quanterix 2020) Months to/since onset Serum pNfH concentration (Euroimmun 2019 [26]) Months to/since onset Serum pNfH concentration (ProteinSimple 2020) Months to/since onset Months to/since onset 30–39 40–49 50–59 60–69 70–79 Age group, years NF neurofilament, NfL neurofilament light chain, pNfH phosphorylated neurofilament heavy chain 1 3 disease. ..



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( A ) Comparison of <t>serum</t> <t>NFL</t> between healthy controls (Controls, N = 55) and hospitalized patients with COVID-19 (mean NFL per patient, N = 142). Bars represent mean NFL concentrations with 95% CIs. Statistical differences were assessed using a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. **** P < 0.001. ( B ) Serum NFL in 35 patients to highlight the range of NFL concentrations in longitudinally collected samples. The first and last NFL concentrations are indicated by a black and red dot, respectively, and mean concentrations for each patient are presented by the small black solid horizontal lines. ( C ) Serum NFL trends over time in the 35 patients with COVID-19 with longitudinal blood draws and for whom at least one NFL measurement is at least 3 SDs above the group mean of NFL in control individuals. NFL concentrations are shown on the base 10 logarithmic scale. The NFL concentration representing the mean control NFL + 3 SDs is indicated by a solid blue horizontal line.
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Image Search Results


Characteristics of patients with CIDP and healthy controls.

Journal: European Journal of Neurology

Article Title: Serum glycobiomarkers for chronic inflammatory demyelinating polyneuropathy

doi: 10.1111/ene.70023

Figure Lengend Snippet: Characteristics of patients with CIDP and healthy controls.

Article Snippet: The serum NfL protein concentrations were measured in duplicate using the Simoa HD‐1 Analyzer (Quanterix, Lexington, MA, USA) and ultrasensitive paramagnetic bead‐based enzyme‐linked immunosorbent assay as performed by researchers blinded to all clinical data.

Techniques: Control, Sampling

( A ) Comparison of serum NFL between healthy controls (Controls, N = 55) and hospitalized patients with COVID-19 (mean NFL per patient, N = 142). Bars represent mean NFL concentrations with 95% CIs. Statistical differences were assessed using a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. **** P < 0.001. ( B ) Serum NFL in 35 patients to highlight the range of NFL concentrations in longitudinally collected samples. The first and last NFL concentrations are indicated by a black and red dot, respectively, and mean concentrations for each patient are presented by the small black solid horizontal lines. ( C ) Serum NFL trends over time in the 35 patients with COVID-19 with longitudinal blood draws and for whom at least one NFL measurement is at least 3 SDs above the group mean of NFL in control individuals. NFL concentrations are shown on the base 10 logarithmic scale. The NFL concentration representing the mean control NFL + 3 SDs is indicated by a solid blue horizontal line.

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: ( A ) Comparison of serum NFL between healthy controls (Controls, N = 55) and hospitalized patients with COVID-19 (mean NFL per patient, N = 142). Bars represent mean NFL concentrations with 95% CIs. Statistical differences were assessed using a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. **** P < 0.001. ( B ) Serum NFL in 35 patients to highlight the range of NFL concentrations in longitudinally collected samples. The first and last NFL concentrations are indicated by a black and red dot, respectively, and mean concentrations for each patient are presented by the small black solid horizontal lines. ( C ) Serum NFL trends over time in the 35 patients with COVID-19 with longitudinal blood draws and for whom at least one NFL measurement is at least 3 SDs above the group mean of NFL in control individuals. NFL concentrations are shown on the base 10 logarithmic scale. The NFL concentration representing the mean control NFL + 3 SDs is indicated by a solid blue horizontal line.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay

Comparison of  serum NFL  between healthy controls and patients with COVID-19. In unadjusted analyses, P values result from a Wilcoxon rank sum test. In adjusted analyses, P values result from a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. N/A, not applicable.

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Comparison of serum NFL between healthy controls and patients with COVID-19. In unadjusted analyses, P values result from a Wilcoxon rank sum test. In adjusted analyses, P values result from a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. N/A, not applicable.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques:

Associations between  serum NFL  and outcomes in patients with COVID-19. For descriptive summaries of NFL concentration and for ease of presentation, LOS was categorized using the sample median, whereas mRS at discharge was categorized using a predefined cutoff of interest. Associations of intubation, ICU admission, LOS, and mRS at discharge (all as independent variables) with NFL concentration (as the dependent variable) were evaluated using linear regression models (for the continuous mean NFL per patient, minimum NFL per patient, and maximum NFL per patient variables) and logistic regression models (for the binary occurrence of an NFL value >25th percentile and occurrence of an NFL value >75th percentile variables). Regression coefficients are interpreted as the change in the mean NFL outcome measure (on the natural logarithmic scale) corresponding to the presence of the given characteristic (intubation and ICU admission), to each doubling of LOS, and to each 1-unit increase in mRS at discharge. CI, confidence interval; CKD, chronic kidney disease. P values <0.0025 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Associations between serum NFL and outcomes in patients with COVID-19. For descriptive summaries of NFL concentration and for ease of presentation, LOS was categorized using the sample median, whereas mRS at discharge was categorized using a predefined cutoff of interest. Associations of intubation, ICU admission, LOS, and mRS at discharge (all as independent variables) with NFL concentration (as the dependent variable) were evaluated using linear regression models (for the continuous mean NFL per patient, minimum NFL per patient, and maximum NFL per patient variables) and logistic regression models (for the binary occurrence of an NFL value >25th percentile and occurrence of an NFL value >75th percentile variables). Regression coefficients are interpreted as the change in the mean NFL outcome measure (on the natural logarithmic scale) corresponding to the presence of the given characteristic (intubation and ICU admission), to each doubling of LOS, and to each 1-unit increase in mRS at discharge. CI, confidence interval; CKD, chronic kidney disease. P values <0.0025 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay

Comparison of  serum NFL concentrations  according to COVID-19 treatment. Regression coefficients, 95% CIs, and P values result from linear regression models, where NFL was the dependent variable. Regression coefficients are interpreted as the difference in mean NFL concentration (on the natural logarithmic scale) between patients who had the given treatment and patients who did not have the given treatment. P values <0.0063 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Comparison of serum NFL concentrations according to COVID-19 treatment. Regression coefficients, 95% CIs, and P values result from linear regression models, where NFL was the dependent variable. Regression coefficients are interpreted as the difference in mean NFL concentration (on the natural logarithmic scale) between patients who had the given treatment and patients who did not have the given treatment. P values <0.0063 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay